Bruce Payne has worked extensively in film, theatre and television in both the UK and the US, and on location in many parts of the world. Most recently, he starred in the live action feature film Riders, with Natasha Henstridge and Stephen Dorff and has also appeared in Doug Aarniokski's Highlander, Endgame, Dungeons and Dragons alongside Jeremy Irons, Thora Birch and Marlon Wayans, and Hellborn. Other film credits include Kevin Hooks' Passenger 57, Apocalypse with the late Sir Richard Harris, Julien Temple's Absolute Beginners, The Brothel, Switch, with Ellen Barkin and Kounterfeit with Hilary Swank.

Television credits include leading roles in Simon West's "Keen Eddie" which airs in January 2003, Oscar Wilde and Smart Money for the BBC, and Tales from the Crypt for HBO. Theatre credits include the lead in London's West End productions “West and Greek”, and the lead in Nicholas Hytner's Alice, as well as playing "Frank'n'furter" in the Rocky Horror Show